Lines accurate as of Wednesday 9:00 ET*
Green Bay (-3) @ Detroit
Niko: Very interesting game. Detroit has looked more than competent over the last three weeks and Green Bay has basically looked dysfunctional for a month. There are a ton of reasons to go with the Lions here, especially getting points at home, but I just can’t. Packers get back on track this Thursday night.
Pete: I want to pick Detroit, especially at home, but I just can't do it. The Packers are still kind of the Packers, right? If they lose this game, expect hell in Green Bay.
Houston (+3) @ Buffalo
Niko: The Texans have arrived. Four straight big wins have this team tied atop the feeble AFC South. I think they get it done on Sunday, as Rex’s crew already lost their Super Bowl Week 11. Houston gets the big road win.
Pete: I think this game pretty much decides both teams' seasons. If Houston wins, the AFC South is right there for the picking. If they lose, they could be demoralized and the Pats may have their way with them. For Buffalo, the AFC East is lost, but they could still sneak into the Wild Card if they play great for the next couple of weeks. I just don't see it, though. I have lost my faith in Rex Ryan.
San Francisco (+7) @ Chicago
Niko: Both teams have looked very competitive recently, with Chicago taking down Green Bay on the road last week, and San Fran almost upsetting the Cardinals. I think Chicago is the better team, and will win the game, but it’ll be ugly and close. I’ll take the points and go with the 49ers.
Pete: Surprsingly, Chicago has been rolling as of late. At home, against arguable the worst team in the NFL, I don't see that changing. Chicago big here.
Cincinnati (-7) @ Cleveland
Niko: After running out of things to do and begrudgingly tuning in for the last few minutes of Monday Night’s Cleveland/Baltimore game, I can never pick the Browns again. Cincy covers on the road.
Pete: The Bengals should roll. Browns are an absolute joke. On a side note, it must be terrible to live in Cleveland. I mean, you really don't have much to look forward to. I guess you have Lebron, but you sure as hell aren't beating Golden State. How about them Indians?
Jacksonville (+2.5) @ Tennessee
Niko: Going with the road team here. Allen Robinson and Julius Thomas will be too much for the Titans’ secondary. Jags get the W.
Pete: Such a bad game. I mean, truthfully, do people in Jacksonville or Tennessee even care about this game? If you want, there is still room on the Patriots bandwagon...
Arizona (-5.5) @ St. Louis
Niko: Describing the St. Louis quarterback play as anemic is really not fair to the word anemic. Cardinals cover on the road.
Pete: Should be a pretty decent game. If this was in Arizona, I wouldn't even think twice about picking the Cardinals. However, St. Louis has put together a decent season and found a franchise player in Todd Gurley. I will go with Arizona, but won't be surprised if the Rams pull it off.
Baltimore (+4) @ Miami
Niko: Dolphins cover at home against the Baltimore B Team. Now that the games are officially meaningless, and draft position is the priority, the Dolphins will start to play well. That’s what bad franchises do. Could be worse though, could owe an underachieving Quarterback and “me-first” d-lineman 180 million for the next 5 years…
Pete: Two bottom-feeders in the NFL. Joy. Baltimore may legitimately be the worst team in the NFL now, so I will take Miami. Like Niko said, when they are out of it, they are usually a decent team.
Seattle (off) @ Minnesota
Niko: Minnesota seems for real. AP is BALLING and they’re winning the games they are supposed to win. Hosting a banged up Seahawks team that still hasn’t found its identity is another winnable game for the Vikings. Minny gets it done.
Pete: Seattle just isn't the same team anymore. With Jimmy Graham going down and already without Marshawn Lynch, I think they will have an extremely tough time moving the football. Adrian Peterson is playing out of his mind and Teddy B looks like a great quarterback for the future. Minnesota.
New York Jets (-2) @ New York Giants
Niko: The Pats killed the Giants. Their season is over. Jets win this interstate showdown.
Pete: To be honest, this may be the Game of the Week. Both teams have a ton to play for, but, I think that the Jets get it done. The Giants are wildly inconsistent, but if they somehow get into the playoffs, look out.
Atlanta (+2) @ Tampa Bay
Niko: Atlanta will hit rock bottom this weekend and get swept by the Bucs this season.
Pete: Surprisingly, the Bucs are playing pretty decent football right now. At home, against a struggling Falcons club, I will take the Bucs in a close one.
Kansas City (-3) @ Oakland
Niko: This is an underrated game that holds legitimate playoff implications. I’ll go with the climbing Oakland Raiders and their talented offense at home this Sunday.
Pete: I want to pick Oakland, but I just don't think they are there yet. They are close, but they need more time to develop. While i don't think that the Chiefs are the Patriots, they have a solid team on both sides of the ball. Chiefs in a good one. (Sneaky Great Game of the Week?)
Denver (-4) @ San Diego
Niko: San Diego does the Patriots a favor and upsets their division rivals this weekend. In the expected absence of Bronco safety TJ Ward, Antonio Gates goes off at home this Sunday. This is assuming Dictator Goodell doesn’t have Denver in the over again.
Pete: I would LOVE if the Chargers win here, but I just don't see how they pull it off. Osweiler is an ASU guy and has never been exposed to terrible conditions like he was last week. When he lands in San Diego and feels that 75 degree warmth, he will be right at home. Broncos, unfortunately.
Philadelphia (+10) @ New England
Niko: The Eagles are in the wrong place and the wrong time. Pats cover. Extended thoughts coming in the Roundtable set to drop this weekend.
Pete: Any other week I would say that this could be a sneaky great game just because of Philly's potential. But the Eagles' inconsistency coupled with how pissed off the Pats are cooks up a recipe for disaster. Pats cover.
Carolina (-7) @ New Orleans
Niko: This prediction will almost certainly blow up in my face, but without rhyme or reason, I’m going with Drew Brees and the New Orleans Saints at home to end the Panthers’ undefeated season. I still think Carolina is overrated. Right, guys…?
Pete: I hate the Panthers. They are probably good for the league, but their brand of football pisses me off. Quarterbacks aren't supposed to run a college-style offense in the NFL. Whatever, they will cover. New Orleans sucks.
Indianapolis (+10) @ Pittsburgh
Niko: I expect the Pittsburgh offense to explode at home on Sunday night. 35+ for Roethlisberger and co. They’ll cover.
Pete: Indy is in a world of hurt right now. They just came off a win against the Bucs, but I wasn't that convinced. If Big Ben (concussion) plays, Pitt should be fine. However, if Roethlisberger can't go, this game could get interesting...
Dallas (+4.5) @ Washington
Niko: The Washington Redskins may win the NFC East. Read that sentence one more time. I know, I can’t believe it either. Led by their pass rush and passing game, the Redskins get it done against the Romo-less Cowboys this weekend.
Pete: How can we have such terrible Monday Night Football games? I get that this game has some serious playoff implications, but these two teams just flat out suck. The Redskins may win, but America loses.